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Cell disruption of bacteria, yeast, filamentous fungi or microalgae is a standard procedure in basic biological research, applied biotechnology or medical research to get access to nucleic acids (DNA, RNA) or cell proteins. For the isolation of DNA or RNA usually less than 1 ml of cell material is needed. For the extraction of proteins, however, larger amounts of cell suspension are required. A very efficient method of cell disruption is the co called “bead beating” where cells in suspension are mechanically disrupted by glass beads in single-use reaction vials.